TABLE 1.
Clinical and demographic characteristics of HIV-1- and HIV-2-infected patients
| Characteristic | All patients
|
CD4-matched patients
|
||||
|---|---|---|---|---|---|---|
| HIV-1 infected (n = 17) | HIV-2 infected (n = 17) | Pe | HIV-1 infected (n = 7) | HIV-2 infected (n = 7) | Pe | |
| No. (%) of patients in Senegalese cohorta | 17 (100) | 10 (59) | 7 (100) | 2 (29) | ||
| No. (%) of patients in Belgian cohort | 0 (0) | 7 (41)b | 0 (0) | 5 (71)c | ||
| Median age in yr (IQR) | 35 (30-39) | 43 (41-47) | <0.001 | 32 (35-40) | 41 (41-43) | 0.047 |
| No. (%) of male subjects | 6 (35) | 5 (29) | 0.921 | 3 (43) | 4 (57) | 1.000 |
| No. (%) of patients with use of ARV | 9 (53) | 5 (29) | 0.125 | 5 (71) | 5 (71) | 1.000 |
| Median CD4+ T cells/μl (IQR) | 302 (109-486) | 781 (440-1,088) | 0.002 | 304 (426-571) | 309 (456-616) | 0.848 |
| No. of patients with CD4+ T cells/μl: | ||||||
| Missing data | 1 | 3 | 0 | 0 | ||
| <200 | 6 | 1 | 1 | 1 | ||
| 200-500 | 6 | 3 | 3 | 3 | ||
| >500 | 4 | 10 | 3 | 3 | ||
| Median CD8+ T cells/μl (IQR) | 1,093 (765-1,398) | 1,108 (948-1,378) | 0.708 | 790 (1,184-1,247) | 601 (1,095-1,516) | 0.949 |
| Median log10 RNA copies/ml (IQR)d | 4.03 (1.70-5.10) | 2.36 (2.36-2.36) | 0.018 | 1.70 (1.70-1.70) | 2.36 (2.36-3.11) | 0.528 |
| No. of patients with log10 RNA copies/ml: | ||||||
| Missing data | 4 | 2 | 1 | 1 | ||
| Undetectable | 6 | 13 | 5 | 4 | ||
| Undetectable, −10,000 | 0 | 1 | 0 | 1 | ||
| 10,000-100,000 | 4 | 0 | 1 | 0 | ||
| 100,000-1,000,000 | 2 | 1 | 0 | 1 | ||
| >1,000,000 | 1 | 0 | 0 | 0 | ||
a
All patients are of West African origin.
b
Three patients are West African, three are European, and one is Central American.
c
Two patients are West African, two are European, and one is Central American.
d
The viral load detection limits were 1.7 log10 RNA copies/ml for HIV-1 and 2.36 log10 RNA copies/ml for HIV-2.
e
P, level of significance for Mann-Whitney U tests or Fisher exact tests.