TABLE 2.
Simulation of restriction in mixed viral populations containing pure cores
| hCA virus/ sCA virus ratio | % Infection in:
|
Fold restrictionb (control cells/TRIM5α cells) | |||||
|---|---|---|---|---|---|---|---|
| Control cells
|
TRIM5α-expressing cellsa
|
||||||
| From hCAc | From sCA | Total | From hCA | From sCA | Total | ||
| 1:1 | 5 | 5 | 10 | 0.125 | 5 | 5.125 | ∼2 |
| 1:2 | 5 | 10 | 15 | 0.125 | 10 | 10.125 | ∼1.5 |
| 1:4 | 5 | 20 | 25 | 0.125 | 20 | 20.125 | ∼1.125 |
a
An assumption of 50-fold restriction is made.
b
For simplicity, percentages of infected cells instead of MOIs are used to calculate restriction in these examples.
c
From a virus containing hCA cores.