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. 2008 Aug 25;2008:203514. doi: 10.1155/2008/203514

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Copyright © 2008 D. A. Caruana and C. A. Chapman.

This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Dopamine has dose-dependent and bidirectional effects on the amplitude of mixed EPSPs in layer II fan cells. (a) Fifty μM dopamine significantly reduces the amplitude of synaptic responses. Traces show averaged EPSPs before (ACSF) and after 5-minute bath application of dopamine (DA) in a representative cell. Group data indicate the mean amplitude of EPSPs before and after dopamine (*, P < .001). Bars indicate ± 1 SEM in this and subsequent figures, and * indicates P < .05 unless otherwise indicated. (b) A lower concentration of 10 μM dopamine causes a smaller suppression of synaptic responses. (c) The low 1 μM concentration of dopamine enhances the amplitude of synaptic responses (*, P < .01). (d) Bath application of vehicle (50 μM sodium metabisulfite; Veh) does not significantly affect synaptic transmission.