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. 2008 Jun 5;295(2):G348–G356. doi: 10.1152/ajpgi.00079.2008

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Fig. 1. — Comparison of Na⁺ transport and short-circuit current (I_sc) across isolated, short-circuited distal colon from control rats with 2 intact kidneys (CON, n = 7), 5/6 nephrectomized rats with chronic renal failure (CRF, n = 11), and rats with renal failure that were treated with losartan (10 mg/kg) for 7 days before euthanasia (+LOS, n = 10). Error bars represent ±1 SE of the mean of data in each group. An asterisk indicates a significant difference compared with CON, and § indicates a significant difference from CRF in a one-way ANOVA (P ≤ 0.05). Transepithelial conductance (G_T) was not significantly affected in CRF (9.00 ± 0.62 mS/cm²) or + LOS (8.23 ± 0.66 mS/cm²) compared with CON (8.79 ± 0.83 mS/cm²). The fluxes and electrical parameters measured in + LOS are not significantly different compared with CON. J, mucosal to serosal flux; J, serosal to mucosal flux; J, net flux.

Inline graphic — Comparison of Na⁺ transport and short-circuit current (I_sc) across isolated, short-circuited distal colon from control rats with 2 intact kidneys (CON, n = 7), 5/6 nephrectomized rats with chronic renal failure (CRF, n = 11), and rats with renal failure that were treated with losartan (10 mg/kg) for 7 days before euthanasia (+LOS, n = 10). Error bars represent ±1 SE of the mean of data in each group. An asterisk indicates a significant difference compared with CON, and § indicates a significant difference from CRF in a one-way ANOVA (P ≤ 0.05). Transepithelial conductance (G_T) was not significantly affected in CRF (9.00 ± 0.62 mS/cm²) or + LOS (8.23 ± 0.66 mS/cm²) compared with CON (8.79 ± 0.83 mS/cm²). The fluxes and electrical parameters measured in + LOS are not significantly different compared with CON. J, mucosal to serosal flux; J, serosal to mucosal flux; J, net flux.