Fig. 2.
Acute serosal losartan (10−4 M) reduces net sodium absorption and Isc across distal colonic tissues removed from CRF rats (n = 11). Error bars represent ±1 SE above or below the mean of data in each group. An asterisk indicates a significant difference between the control period of 45 min (Per I) (CRF) and the second 45-min flux period (Per II) (+LOS), using a paired t-test, P ≤ 0.05. Transepithelial conductance (GT) was not significantly changed in Per II (8.23 ± 0.66 mS/cm2) compared with Per I (9.00 ± 0.62 mS/cm2).