Fig. 4.
Mucosal EIPA (50 μM) partially reduces net sodium absorption in the distal colon of CRF rats (n = 7). Indomethacin was present in this series (5 μM, serosal) to better resolve any changes in Isc that might result from EIPA inhibition of electrogenic Na+ absorption. Error bars represent ±1 SE above or below the mean of data in each group. An asterisk indicates a significant difference between Per I (CRF) and Per II (+EIPA), using a paired t-test, P ≤ 0.05. Transepithelial conductance (GT) was not significantly changed in Per II (7.82 ± 0.90 mS/cm2) compared with Per I (8.62 ± 0.77 mS/cm2).