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Mucosal amiloride (10−4 M) partially reduces net sodium absorption and Isc in the distal colon of CRF rats (n = 7). Error bars represent ±1 SE above or below the mean of data in each group. An asterisk indicates a significant difference between Per I (CRF) and Per II (+Amiloride), using a paired t-test, P ≤ 0.05. Transepithelial conductance (GT) was not significantly changed in Per II (9.58 ± 1.09 mS/cm2) compared with Per I (10.13 ± 1.13 mS/cm2).
