Table 2.
Comparison of overall fluid and sodium balance, blood pressure, and renal function in CON, CRF, and + LOS groups
| Group | CON | CRF | + LOS |
|---|---|---|---|
| SNa+, mmol/l | 146.5±1.8 | 147.9±1.7 | 145.2±1.7 |
| UNa+, μmol/24 h | 1237±109 | 1929±285* | 1289±98 |
| SCr, μmol/l | 43.3±4.3 | 125.0±7.3* | 84.2±6.1*† |
| Cr Clear, ml/min | 2.50±0.28 | 0.94±0.08* | 1.38±0.18* |
| UV, ml/24 h | 13.5±1.1 | 50.2±3.8* | 44.8±4.2* |
| H2O intake, ml/24 h | 36.7±1.8 | 79.5±9.2* | 71.5±6.9* |
| Food intake, g/24 h | 21.3±0.5 | 22.9±0.9 | 21.4±1.0 |
| Δ Body wt, g | 75.7±10.3 | 50.2±8.0 | 52.7±11.9 |
| BP, mmHg | 121.7±9.5 | 195.0±10.5* | 150.0±3.4† |
Values are means ± SE. CON, control; CRF, chronic renal failure; +LOS, losartan; SNa+, serum sodium; UNa+, urinary sodium excretion; SCr, serum creatinine; Cr Clear, creatinine clearance; UV, urinary volume excretion; Δ Body Wt, the gain in body weight over the 6-week period following 5/6 nephrectomy; BP, mean arterial systolic blood pressure.
*
Significant difference from control, P ≤ 0.05;
†
significant difference from CRF, P ≤ 0.05.