Fig. 5.

MUP-iCre-AAV8 delivery has little associated liver toxicity. A: hematoxylin and eosin staining of livers from vehicle-injected, empty MUP-AAV8, and MUP-iCre-AAV8 mice after 31 days demonstrates comparable cellular architecture with no inflammatory cell infiltrate. Original magnification 400×. B: serum levels of alanine aminotransferase (ALT), aspartate aminotransferase (AST), and total bilirubin 1, 4, 7, and 31 days after injection of vehicle, 1.4 × 10¹⁰ DRP MUP-iCre-AAV8/mouse, or 2.2 × 10¹¹ DRP empty MUP-AAV8/mouse. Data are compiled from 3–4 mice in each treatment group. Reference levels are indicated in the text.