Table 3.
Comparison of the properties of ion channels activated by lubiprostone
| Property | ClC-2 | CFTR | Notes |
|---|---|---|---|
| Unit conductance | 3–4 pS | 7–9 pS | maximum conductance (outward current for CFTR; inward current for ClC-2) |
| Voltage dependence | Po decreases with depolarization | none | |
| Selectivity | Cl>Br>NO3>I>SCN | Cl>Br>>NO3=I=SCN | |
| Blockers | DPC, glibenclamide, I−, SCN− | DPC, glibenclamide | reduces open time |
| Rectification | inward | outward | |
| Other | “double-barreled” | burst behavior at negative potentials | |
| Frequency in treated patches | >80% | about 30% |
Po, open probability.