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One step growth curves of wt poliovirus and a 3A mutant (W42F/F69W/A70V). Growth curves and plaque assays were carried out as described in Experimental Procedures. Upper panel: growth at 37 °C. Lower panel: growth at 39 °C. Note that this 3A mutant also has a suppressor mutation (I47V) within the first hydrophobic domain of the 2B-coding sequence (Fig. 1A). The Y-axis shows pfu/ml in exponential units (base 10).
