TABLE 3.
DNA damage 8-OHdG according to PPARGC1A genotypes
| Genotype | n | Damage (ng/μg) | P value | Adjusted P value* | |
|---|---|---|---|---|---|
| m9722 | AA + AC | 309 | 164.8 ± 6.8 | 0.756 | 0.705 |
| CC | 622 | 167.0 ± 5.9 | |||
| m1668 | AA + AG | 427 | 172.1 ±6.1 | 0.010 | 0.008 |
| GG | 506 | 159.0 ± 6.3 | |||
| i5378 | GG | 320 | 167.0 ± 6.5 | 0.850 | 0.829 |
| GT | 423 | 164.8 ± 6.4 | |||
| TT | 192 | 168.0 ± 7.5 | |||
| i15867 | CC | 669 | 166.6 ± 5.9 | 0.123 | 0.104 |
| CT + TT | 272 | 159.2 ± 6.9 | |||
| i27289 | AA | 356 | 164.3 ± 6.6 | 0.739 | 0.704 |
| AG | 437 | 167.1 ± 6.2 | |||
| GG | 147 | 165.1 ± 7.8 | |||
| i55301 | AA | 355 | 173.0 ± 6.3 | 0.012 | 0.014 |
| AG + GG | 581 | 160.0 ± 6.0 | |||
| G482S | CC | 473 | 163.1 ± 6.4 | 0.103 | 0.109 |
| CT | 384 | 168.7 ± 6.5 | |||
| TT | 77 | 181.9 ± 9.7 | |||
| T612M | AA + AG | 112 | 156.4 ± 8.6 | 0.114 | 0.138 |
| GG | 826 | 167.5 ± 5.8 | |||
| 3U4898 | AA + AG | 79 | 150.9 ± 9.6 | 0.030 | 0.034 |
| GG | 866 | 167.9 ± 5.8 |
Data are means ± SE. All means and P values calculated by ANCOVA using general linear models and adjusted for age, sex, BMI, smoking, alcohol use, physical activity, depression medication, and population admixture. n, sample size.
*
P values were calculated adjusted for additional covariates: type 2 diabetes and CVD.