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. Author manuscript; available in PMC: 2009 Aug 1.
Published in final edited form as: Neurosci Lett. 2008 May 15;440(2):113–118. doi: 10.1016/j.neulet.2008.05.031

Figure 4.

Figure 4

Actin dynamics and HSV-1 viral spread. A, The F-actin fluorescence increases dramatically as a function of viral dose relative to uninfected controls. Viral dose was estimated in plaque-forming units (PFU) per P19 cell. A higher expression of F-actin implies filopodia formation and actin cortex reorganization in response to increasing HSV-1 concentrations. B, The actin polymerization inhibitor cytochalasin D greatly reduces viral entry, implicating actin dynamics in viral infection strategies in P19 neural cell cultures. Cytochalasin D prevented both surfing behavior and filopodia formation after HSV-1 application.