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. Author manuscript; available in PMC: 2009 Mar 19.
Published in final edited form as: J Mol Biol. 2008 Apr 11;381(5):1382–1394. doi: 10.1016/j.jmb.2008.04.016

Fig. 7.

Fig. 7

Structural models for binding of sialosaccharides in the RBD of the Viet04 HA. Truncated fragments of human lactoseries tetrasaccharides a and c (LSTa and LSTc) receptor analogs were modeled into the RBD of the Viet04 strain (PDB:2FK0 11) by superimposing the structures of H5 A/Duck/Singapore/3/97 and H9 A/Swine/Hong Kong/9/98 HAs (PDB:1JSN and 1JSI 31) with α2-3 and α2-6 analogs bound. Residues were substituted from the Viet04 model (A) to yield a model for (B) the mutant RLS. Putative hydrogen bonds between the sialoside and the RBD are shown as hashed green lines. Figures were generated with MacPymol 42.