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. Author manuscript; available in PMC: 2008 Aug 25.
Published in final edited form as: J Am Chem Soc. 2007 Mar 31;129(16):4961–4972. doi: 10.1021/ja066929m

Scheme 1.

Scheme 1

Basis for targeted drug delivery in metastatic melanoma cells. a, α1(IV)1263-1277 PA sequence and triple-helical structure. b, Fluorophore loaded liposome. c, Fluorophore loaded liposome with α1(IV)1263-1277 PA. d, Metastatic melanoma cell with overexpressed CD44/CSPG receptors. Rhodamine internalization may proceed by one of three possible routes: (i) direction fusion of the liposome with the cell bilayer and rhodamine release; (ii) liposome binding to CD44/CSPG receptors, followed by fusion of the liposome with the bilayer and rhodamine release; or (iii) liposome binding to CD44/CSPG receptors, followed by internalization of the receptor/liposome complex and rhodamine release in endosomes.