Table 1.
Adjusted rCBF by Condition in Brain Regions That Were Significantly Different between p-HD and Controls
| p-HD | Controls | ||||||
|---|---|---|---|---|---|---|---|
| Region | SEQ | CCW | Δa | SEQ | CCW | Δa | pb |
| Mediodorsal thalamus | 85.4 ± 3.0 | 83.8 ± 3.3 | 1.9 | 83.4 ± 4.0 | 85.3 ± 3.9 | −2.2 | < 0.0001 |
| Orbitofrontal cortex | 68.2 ± 2.6 | 67.1 ± 3.2 | 1.6 | 66.7 ± 5.4 | 69.0 ± 4.9 | −3.2 | 0.0002 |
Values represent mean adjusted rCBF (ml/min)/100g ± SD recorded during the performance of a motor SEQ and a CCW (see text).
a
(SEQ – CCW)/CCW χ 100%.
b
Group χ task interaction.
rCBF = regional cerebral blood flow; p-HD = presymptomatic Huntington's disease; SEQ = sequence learning task; CCW = motor execution reference task.