Table 5.
ASR-PPI settings in the participating centers
| Testing Conditions | CNR | GSF | ICS | MRC |
|---|---|---|---|---|
| Startle device | SR-Lab | Med Associates | SR-Lab | custom made |
| Animal enclosure/inside diam., cm | Plexiglas cylinder, 3.8 | Plexiglas cylinder, 4.3 | Plexiglas cylinder, 3.8 | Plexiglas cylinder, 3.8 |
| Tone frequency | white noise, 0–20 kHz | white noise, 0–20 kHz | white noise, 0–20 kHz | white noise, 0–20 kHz |
| BN, dB | 65 | 40 | 65 | 65 |
| Pulse, 110 dB | 45 dB above the BN | 70 dB above the BN | 45 dB above the BN | 45 dB above the BN |
| Prepulse, 70–90 dB | 5–25 dB above the BN | 30–50 dB above the BN | 5–25 dB above the BN | 5–25 dB above the BN |
ASR, acoustic startle response; PPI, prepulse inhibition; BN, background noise.