Table 2.
Effects of Tas1r3 genotype on preference scores for calcium, magnesium, and saccharin in B6 × PWK F2 mice: QTL LOD scores, percentage of phenotypic variance accounted for, and mean preferences of genotype groups at SNP marker rs13478075 in Tas1r3
| Measure | LOD Score | % Variance | B6/B6 (n = 108) | B6/PWK (n = 256) | PWK/PWK (n = 107) | F(2,468), P |
|---|---|---|---|---|---|---|
| CaCl2 | 7.2* | 7.1 | 27±1 | 34±1a | 40±2ab | 17.9, P < 0.000001 |
| CaLa | 8.4* | 10.1 | 34±2 | 42±1a | 51±2ab | 19.3, P < 0.000001 |
| MgCl2 | 15.9* | 12.6 | 30±1 | 39±1a | 51±2ab | 39.9, P < 0.000001 |
| Saccharin | 12.1* | 10.3 | 82±1 | 83±1 | 74±1ab | 26.7, P < 0.000001 |
Preference values are means ± SE; n = group sizes. %variance = percentage of phenotypic variance accounted for, based on SSbetween/SStotal.
Significance of linkage, P < 0.01;
significant difference between groups of F2 mice with different Tas1r3 genotypes, P < 0.01 relative to B6/B6 group;
P < 0.01 relative to B6/PWK group. Group sizes and degrees of freedom for F-tests were slightly less in some cases because data were lost due to spillage or other technical errors. QTL, quantitative trait locus; LOD, logarithm of the odds ratio; SNP, single nucleotide polymorphism; SS, sum of squares.