Figure 11.

Models depicting the potential functions of GLUT1CBP. (A) GLUT1CBP tethers GLUT1-containing vesicles to cytoskeletal motor proteins. This particular model invokes dimerization of GLUT1CBP and linkage to KIF-1B and the microtubule. An alternative model could be proposed in which monomeric GLUT1CBP links GLUT1 vesicles to myosin VI and actin. (B) GLUT1 is linked to other GLUT1 molecules by GLUT1CBP, resulting in clustering of GLUT1 and perhaps stabilization of the transporter at a specific plasma membrane (PM) domain. (C) GLUT1 is anchored to α-actinin-1 via GLUT1CBP, thus providing linkage to the submembranous actin cytoskeleton.