Table 1.
Intracellular taxol concentration in human tumor cells after incubation for 24 h (or 4 h where noted) in taxol-containing medium and effects on proliferation
| Cell type | Initial taxol concentration in media (nM) | Intracellular taxol concentration (μM) | Degree of concentration |
|---|---|---|---|
| Caov-3 ovarian | 3 | 3.6 ± 0.8 | 1200× |
| carcinoma cells | 10 | 13.5 ± 0.8 | 1350× |
| 30 (4 h) | 10.7 ± 0.7 | ||
| 100 | 47.7 ± 2.2 | 477× | |
| 1000 | 99.7 ± 20.6 | 100× | |
| A-498 kidney | 3 | 1.0 ± 0.1 | 330× |
| carcinoma cells | 10 | 2.8 ± 0.3 | 280× |
| 100 (4 h) | 19.6 ± 2.6 | ||
| 100 | 17.4 ± 1.8 | 174× | |
| 1000 | 67.3 ± 3.6 | 67× |
Values are mean ± SEM.