Table 2.
Effects of taxol on rates of microtubule dynamic instability in human tumor cells
| Parameter | Cell type and taxol concentration
|
|||||
|---|---|---|---|---|---|---|
| A-498 control | A-498 + 100 nM | Change | Caov-3 control | Caov-3 + 30 nM | Change | |
| Growth rate (μm/min) | 8.36 ± 4.2 | 6.83 ± 4.0a | −18% | 8.27 ± 4.5 | 6.30 ± 3.7b | −24% |
| Shortening rate (μm/min) | 9.15 ± 5.1 | 6.74 ± 3.2b | −26% | 11.55 ± 7.3 | 7.91 ± 7.2a | −32% |
The values are expressed as ±SD.
a
Values significant at 95% confidence level (Student’s t test).
b
Values significant at 99% confidence level (Student’s t test).