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. Author manuscript; available in PMC: 2008 Aug 25.
Published in final edited form as: J Med Chem. 2006 Apr 20;49(8):2496–2511. doi: 10.1021/jm0512037

Scheme 3.

Scheme 3

Reagents: (a) 8, TiCl4, Zn, THF, reflux, 4 h; (b) methoxymethyl chloride, NaH, DMF, 0 °C-rt, 1 h; (c) K2CO3, MeOH:H2O (5:1), rt, 12 h; (d) DAST, CH2Cl2, −78 °C-rt, 1 h; (e) HCl, MeOH, rt, 12 h.