Skip to main content
. 2008 Sep 12;4(9):e1000151. doi: 10.1371/journal.ppat.1000151

Figure 3. IFN-λ activates Mx1 gene expression in lung but not liver of IFNAR10/0 mice.

Figure 3

(A) Western blot analysis of Mx1 protein levels in lungs of mice at 20 hours post intranasal application of 3,500 units of IFN-λ3. Animals treated with a mock preparation served as control. Two animals of each group are shown. (B) Mx1 protein levels in the liver of IFNAR10/0 mice at 20 hours post intraperitoneal application of 15,000 units of IFN-λ3 or terminally ill at 72 hours post infection with hepatotropic THOV-ΔML or RVFV clone 13. Two animals for each group are shown. Liver extract from a wild-type mouse killed at 20 hours post intraperitoneal treatment with 100,000 units of human IFN-αB/D served as positive control.