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Extrahelical binding of uracil to the UNG active site and the general strategy for uracil-directed ligand tethering. (A) Structure of UNG bound to uracil (pdb code 2eug). The residue numbering is for the human enzyme. (B) and (C) The uracil ligand (U) that targets the UDG active site is covalently tethered to two different ligands that can interact with distinct binding surfaces near the active site.
