Fig. 4.

Reduced muscarinic type 2 (M2) receptor binding in the cingulate cortex in depressed subjects with bipolar disorder relative to healthy controls. The statistical parametric map shows voxel t values corresponding to areas where the uptake of [¹⁸F]FP-TZTP, a PET radioligand which selectively binds M2 receptors, was significantly reduced (at P < 0.005) in bipolar depressives relative to healthy controls. The areas of maximal difference between groups were located in the anterior cingulate cortex. Reproduced from Cannon et al. (2006a)