Skip to main content
PMC home page
Journal of Bacteriology logoLink to Journal of Bacteriology
. 1968 Sep;96(3):596–605. doi: 10.1128/jb.96.3.596-605.1968

Neisseria gonorrhoeae II. Colonial Variation and Pathogenicity During 35 Months In Vitro

Douglas S Kellogg Jr 1, Irun R Cohen 1, Leslie C Norins 1, Arnold L Schroeter 1, Gilbert Reising 1
PMCID: PMC252347  PMID: 4979098

Abstract

During 35 months of selective in vitro cultivation, Neisseria gonorrhoeae cells retained their virulence for humans and were shown to be closely related to a particular colonial morphology. Saline-autoagglutinability was the only other characteristic distinguishing virulent from avirulent cells. Human responses to challenge with cells of the different colonial types were studied for their relationships to virulence or avirulence.

Full text

PDF
598

Images in this article

598Image
on p.598

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Cohen I. R. Natural and immune human antibodies reactive with antigens of virulent Neisseria gonorrhoeae: immunoglobulins G, M, And A. J Bacteriol. 1967 Jul;94(1):141–148. doi: 10.1128/jb.94.1.141-148.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Cohen I. R., Norins L. C. Natural human antibodies to gram-negative bacteria: immunoglobulins G, A, and M. Science. 1966 May 27;152(3726):1257–1259. doi: 10.1126/science.152.3726.1257. [DOI] [PubMed] [Google Scholar]
  3. DEACON W. E., PEACOCK W. L., Jr, FREEMAN E. M., HARRIS A. Identification of Neisseria gonorrhoeae by means of fluorescent antibodies. Proc Soc Exp Biol Med. 1959 Jun;101(2):322–325. doi: 10.3181/00379727-101-24925. [DOI] [PubMed] [Google Scholar]
  4. DONDERO N. C. SIMPLE AND RAPID METHOD FOR DEMONSTRATING MICROBIAL CAPSULES BY PHASE-CONTRAST MICROSCOPY. J Bacteriol. 1963 May;85:1171–1173. doi: 10.1128/jb.85.5.1171-1173.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. EIGELSBACH H. T., BRAUN W., HERRING R. D. Studies on the variation of Bacterium tularense. J Bacteriol. 1951 May;61(5):557–569. doi: 10.1128/jb.61.5.557-569.1951. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Gould R. G., Kane L. W., Mueller J. H. On the Growth Requirements of Neisseria Gonorrhoeae. J Bacteriol. 1944 Mar;47(3):287–292. doi: 10.1128/jb.47.3.287-292.1944. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hirsch J. G. Phagocytosis. Annu Rev Microbiol. 1965;19:339–350. doi: 10.1146/annurev.mi.19.100165.002011. [DOI] [PubMed] [Google Scholar]
  8. KELLOGG D. S., Jr, DEACON W. E. A NEW RAPID IMMUNOFLUORESCENT STAINING TECHNIQUE FOR IDENTIFICATION OF TREPONEMA PALLIDUM AND NEISSERIA GONORRHOEAE. Proc Soc Exp Biol Med. 1964 Apr;115:963–965. doi: 10.3181/00379727-115-29090. [DOI] [PubMed] [Google Scholar]
  9. KELLOGG D. S., Jr, PEACOCK W. L., Jr, DEACON W. E., BROWN L., PIRKLE D. I. NEISSERIA GONORRHOEAE. I. VIRULENCE GENETICALLY LINKED TO CLONAL VARIATION. J Bacteriol. 1963 Jun;85:1274–1279. doi: 10.1128/jb.85.6.1274-1279.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. LABZOFFSKY N. A., KELEN A. E. New complement fixing antigen for serodiagnosis of gonorrhoea. Can J Microbiol. 1961 Oct;7:715–723. doi: 10.1139/m61-085. [DOI] [PubMed] [Google Scholar]
  11. PAGE L. A., GOODLOW R. J., BRAUN W. The effects of threonine on population changes and virulence of Salmonella typhimurium. J Bacteriol. 1951 Nov;62(5):639–647. doi: 10.1128/jb.62.5.639-647.1951. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. Reising G., Kellogg D. S., Jr Detection of gonococcal antibody. Proc Soc Exp Biol Med. 1965 Dec;120(3):660–663. doi: 10.3181/00379727-120-30617. [DOI] [PubMed] [Google Scholar]
  13. SCHERP H. W. Neisseria and neisserial infections. Annu Rev Microbiol. 1955;9:319–334. doi: 10.1146/annurev.mi.09.100155.001535. [DOI] [PubMed] [Google Scholar]
  14. WHITE L. A., KELLOGG D. S., Jr NEISSERIA GONORRHOEAE IDENTIFICATION IN DIRECT SMEARS BY A FLUORESCENT ANTIBODY-COUNTERSTAIN METHOD. Appl Microbiol. 1965 Mar;13:171–174. doi: 10.1128/am.13.2.171-174.1965. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. WILSON J. F. A serological study of Neisseria gonorrhoeae. J Pathol Bacteriol. 1954 Oct;68(2):495–510. doi: 10.1002/path.1700680222. [DOI] [PubMed] [Google Scholar]
  16. White L. A., Kellogg D. S., Jr An improved fermentation medium for Neisseria gonorrhoeae and other Neisseria. Health Lab Sci. 1965 Oct;2(4):238–241. [PubMed] [Google Scholar]

Articles from Journal of Bacteriology are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES