Figure 8.

Inhibition of neurite outgrowth by mAb LM609 directed against α_vβ₃ integrin. (A) Mean neurite lengths of DRG cells cultured on stimulatory substrates GST-Ig4-5-6, GST-Ig6, or GST-Ig2 in the presence of either mAb LM609 against α_vβ₃ integrin or mAb W1B10 against the chick β₁ integrin subunit. Both antibodies were added at a final concentration of 40 μg/ml. Data represent the mean ± SD of three experiments. (B) Dose effects of mAb LM609 on neurite outgrowth of DRG cells cultured on substrate-coated GST-Ig6.