Figure 1.

(A) The neighbor-joining (NJ) tree dendrogram of the WW domains from human origin. The WW domain sequences from human origin were obtained from the Pfam server (http://www.sanger.ac.uk/Software/Pfam/), and the redundancy was removed using the 100% sequence identity filter. The sequences thus selected were analyzed using the program CLUSTAL W (Thompson et al. 1994). (Magenta) The members of the subclass that contains SAV1 WW2 and MAGI1 WW2. (B) Comparative representation of the LOGO plot of the representative WW domain sequences and the sequences of the members of the subclass that contains SAV1 WW2 and MAG1 WW2. (Yellow boxes) Polar residues of E242 and S246 in SAV1 WW2, as well as those of their counterparts in MAGI1 WW2, E366 and D370. (Red) Acidic residues, (blue) basic residues.