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. 1998 Jul 1;188(1):119–131. doi: 10.1084/jem.188.1.119

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Abrogation of T cell proliferation in response to staphylococcal enterotoxin A (SEA) in CD18 null mice. In A, splenocytes from three wild-type littermates (filled symbols) and from CD18 null mice (open symbols) were cultured without addition or with 0.1 ng to 20 μg/ml SEA. In B, splenocytes from wild-type (filled symbols) or CD18 null (open symbols) mice were stimulated with 100 ng/ml phorbol myristate acetate and 200 ng/ml ionomycin and analyzed for proliferation at the indicated times. Proliferation was quantitated as described in Materials and Methods and is expressed as mean cpm ± SEM of triplicate cultures for three mice of each genotype.