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. 1998 Jul 1;188(1):199–204. doi: 10.1084/jem.188.1.199

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Upregulation of CTLA4 in response to alloantigen by wild-type and CD28-deficient T cells. Splenocytes from wild-type and CD28^−/− mice underwent two rounds of stimulation in vitro with irradiated allogeneic splenocytes, as described in Materials and Methods. 72 h after the second stimulation, samples were analyzed by flow cytometry. The histograms represent the fluorescence emitted by wild-type or CD28-deficient CD4⁺ cells after staining with hamster IgG (thin line) or anti-CTLA4 mAb (heavy line).