Figure 9.

CBF₁ and adjacent residues modeled within the prefusogenic form of PIV5/SV5 F. A) Close-up view of CBF₁ and interacting residues. Purple = CBF₁ and adjacent residues; orange = fusion peptide; green = F103, the first residue of the fusion peptide; yellow = disulfide bond; red = completely conserved residues in CBF₁. B) CBF₁ (purple) in the context of the entire F ectodomain. C) Potential hydrophobic interactions between CBF₁ and flanking residues (purple) and the fusion peptide domain (orange). Hydrophobic residues = green. [Figures were adapted from (26) using PyMOL 0.99 and color coded for clarification.]