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. 2008 Aug 4;205(8):1879–1888. doi: 10.1084/jem.20072646

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© 2008 Lech et al.

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Figure 1. — Lack of Sigirr is associated with massive lymphoproliferation in B6^lpr/lpr mice. (A and B) At 6 mo of age, Sigirr-deficient B6^lpr mice revealed massive hyperplasia of cervical, axillar (A), and mesenteric lymph nodes (B) as well as splenomegaly (B). Data are means ± SEM from 12 mice in each group. *, P < 0.05. (C) PAS staining of spleen sections indicates lymph follicle hyperplasia in Sigirr-deficient B6^lpr/lpr mice. Images in A and C are representative of at least 12 mice in each group. Bars: (B) 1 cm; (C) 100 μm.