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. 2008 Aug 4;205(8):1869–1877. doi: 10.1084/jem.20080178

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© 2008 Björkqvist et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

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Figure 1. — Altered immune profile peripherally in HD. (A) Multiplex ELISA quantification of cytokine levels in plasma from HD patients (premanifest, early and moderate HD stages) compared with control subjects. Graphs show mean concentrations with standard error bars. Significant differences between individual groups are shown (ANOVA with post-hoc Tukey HSD test). (B) The overall trend for increasing levels of cytokines across all groups, analyzed using linear regression, was highly significant for IL-6 and IL-8 and significant for IL-4, IL-10, TNF-α, and IL-5. R-values (partial correlation coefficients) are corrected for age and sex. *, P < 0.05; **, P < 0.01; ***, P < 0.001; ****, P < 0.0001.