Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 2008 Aug 4;205(8):1869–1877. doi: 10.1084/jem.20080178

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

© 2008 Björkqvist et al.

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.jem.org/misc/terms.shtml). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 3.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/3.0/).

PMC Copyright notice

Figure 6. — HD monocytes, macrophages, and microglia are overactive when stimulated. (A) No IL-6 was detectable in the supernatant of monocytes from control (n = 9) or premanifest HD subjects (n = 8) in the unstimulated state or after priming with IFN-γ. Monocytes stimulated by the addition of both IFN-γ and 2 μg/ml LPS expressed IL-6, but expression levels were significantly higher from HD monocytes. (B) Alveolar macrophages from the YAC128 HD mouse model have similarly altered function when stimulated. YAC128 macrophages stimulated by the addition of both IFN-γ and 100 ng/ml LPS expressed significantly more IL-6. n = 3 WT and 4 YAC128. (C) Macrophages from YAC18 mice, which differ from YAC128 cells only in the number of CAG repeats, behaved no differently from WT cells (P = 0.231; n = 4 per genotype) in response to stimulation at the same LPS concentration, suggesting that the hyperactivity in the YAC128 is due to mutant huntingtin. (D) Microglia isolated from neonatal R6/2 mice are also hyperactive when stimulated by 10 ng/ml LPS (n = 4 per group). Graphs show mean concentrations with standard error bars. ND, not detected. Unpaired t tests: *, P < 0.05; **, P < 0.01.