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. 2008 Aug 4;205(8):1869–1877. doi: 10.1084/jem.20080178

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© 2008 Björkqvist et al.

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Figure 9. — Mouse models of HD recapitulate features of human immune dysfunction. Serum levels of cytokines, measured by multiplex ELISA, are elevated in both (A) R6/2 and (B) Hdh^Q150Q/Q150 knock-in mouse models (n = 9 per genotype) at end-stage. (C) In 12-mo YAC128 animals (equivalent to early human disease), serum IL-6 and mKC, a mouse functional homologue of IL-8, are significantly increased (n = 3 WT and 4 YAC128). Graphs show mean levels with standard error bars. Unpaired t tests: *, P < 0.05; **, P < 0.01.