Table I.
Transgenic mice that express the apoL-I gene ameliorate infection with T. brucei, T. evansi, and T. congolense
| Transgenic DNA |
Trypanosome species (1.78 × 106 injected i.p.) |
Number mice alive/ number mice infected |
||
|---|---|---|---|---|
| Day 3 | Day 20 | Day 50 | ||
| ApoL-I | T. brucei | 5/5 | 3/5b | |
| Vector | 0/5a | |||
| ApoL-I | T. brucei SRA | 0/5a | ||
| Vector | 0/5a | |||
| ApoL-I | T. evansi | 5/5 | 4/5c | |
| Vector | 5/5 | 1/5d | ||
| ApoL-I | T. congolense | 5/5 | 3/5b | |
| Vector | 2/5 | 2/5d | ||
Mice expressing the gene for apoL-I were infected with 1.78 × 106T. b. brucei (Lister 427-derived line), T. b. brucei-SRA (Lister 427-derived line expressing the SRA gene), T. evansi (AnTat 3), or T. congolense (STIB 68Q). n = 5 per group.
a
Parasitemia ≥ 1 × 109 before mice were killed.
b
No parasites detectable.
c
Died of unknown cause, did not have detectable parasites.
d
Parasitemia = 1 × 106/ ml.