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Diethylzinc additions to 3'-methylacetophenone under solvent-free and highly concentrated reaction conditions.
 | |||||
|---|---|---|---|---|---|
| entry | solvent | L* (mol %) | time (h) | yield (%) | ee (%) |
| 1 | tol/hex | 2 | 24 | 78 | >99 |
| 2 | none | 1 | 4 | 79 | 99 |
| 3 | 2 equiv tola | 1 | 7 | 78 | 99 |
| 4 | none | 0.5 | 20 | 80 | 98 |
| 5 | none | 0.25 | 21 | 62 | 97 |
| 6 | none | 0.1 | 24 | 58 | 96 |
Two equiv toluene relative to ketone substrate.
