Table 31.

Diethylzinc additions to ketones under solvent-free, highly concentrated, and standard conditions.

solvent-free or highly concentrated conditions						standard conditions
entry	substrates	L* (moi%)	t (h)	y (%)	ee (%)	L*(mol%)	t (h)	y (%)	ee (%) (config.)
1	X = H	1 0.5	4 21	75 78	97a 96a	2	29	71	96 (S)
2	X = 3-CF3	0.5	17	77	96a	2	14	56	98
3	X = 4-OMe	1 1	12 15	50 72	81a 89b	10	111	85	94
4		0.5 0.5	12 24	74 76	98a 98b	2	27	90	97
5		1 1	24 24	78 85	80a 80b	2	102	79	88 (R)
6		1	15	71	90b	2	26	80	90
7		1	22	53	93b	2	46	56	96
8		1	22	36	96b	10	40	76	98

^aSolvent-free conditions.

^b2 Equiv toluene was added to the reaction.