. Author manuscript; available in PMC: 2008 Aug 26.

Published in final edited form as: Chem Rev. 2007 May 27;107(6):2503–2545. doi: 10.1021/cr0509556

Table 31.

Diethylzinc additions to ketones under solvent-free, highly concentrated, and standard conditions.


solvent-free or highly concentrated conditions						standard conditions
entry	substrates	L* (moi%)	t (h)	y (%)	ee (%)	L*(mol%)	t (h)	y (%)	ee (%) (config.)

1	X = H	1 0.5	4 21	75 78	97^a 96^a	2	29	71	96 (S)
2	X = 3-CF₃	0.5	17	77	96^a	2	14	56	98
3	X = 4-OMe	1 1	12 15	50 72	81^a 89^b	10	111	85	94
4		0.5 0.5	12 24	74 76	98^a 98^b	2	27	90	97
5		1 1	24 24	78 85	80^a 80^b	2	102	79	88 (R)
6		1	15	71	90^b	2	26	80	90
7		1	22	53	93^b	2	46	56	96
8		1	22	36	96^b	10	40	76	98

Solvent-free conditions.

2 Equiv toluene was added to the reaction.