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Catalytic asymmetric allylation of 3'-methylacetophenone from Eq 14.
| entry | solvent | Ti(Oi-Pr)4 (mol %) |
BiNOL (mol %) |
IPA (equiv) |
% ee (% yield) |
|---|---|---|---|---|---|
| 1 | CH2Cl2 | 20 | 20 | 20 | 96 (82) |
| 2 | 20 | 20 | 3 | 94 (91) | |
| 3 | 10 | 10 | 20 | 88 (94) | |
| 4 | 10 | 10 | 3 | 81 (86) | |
| 5 | no CH2Cl2 | 20 | 20 | 20 | 85 (91) |
| 6 | concentrated | 10 | 10 | 3 | 81 (88) |
| 7 | 5 | 5 | 3 | 79 (84) | |
