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Optimization of the asymmetric allylation of 3-methylacetophenone (Eq 14) by variation of the Ti: BINOL and the mol% catalyst loading.
| entry | Ti(Oi-Pr)4 (mol %) |
BINOL (mol %) |
IPA (equiv) |
% ee (% yield) |
|---|---|---|---|---|
| 1 | 10 | 10 | 3 | 88 (88) |
| 2 | 10 | 20 | 3 | 95 (93) |
| 3 | 5 | 10 | 3 | 90 (90) |
| 4 | 2 | 4 | 3 | 55 (97) |
| 5 | 1 | 2 | 3 | 28 (95) |
