Table 46.
Results from the catalytic asymmetric hydrogenaiton of imines under solvent-free and highly concentrated conditions with precatalysts A-C (Figure 43).
 | |||||
|---|---|---|---|---|---|
| substrate | precat. | S : Ca | conv (%) | time (h) | ee (%) |
 |
A | 5,000 | 100 | <12 | 52 |
 |
A | 3,600 | 100 | <12 | 46 |
 |
A | 5,000 | 87 | 48 | 50 |
 |
A | 5,000 | 100 | <12 | 88 |
| B | 5,000 | 100 | <12 | 73 | |
 |
A | 5,000 | 100 | <12 | 60 |
| B | 5,000 | 100 | <12 | 64 | |
 |
A | 500 | 100 | 36 | 71 |
| B | 500 | 90 | 72 | 70 | |
 |
A | 500 | 100 | 36 | 60 |
| B | 500 | 90 | 24 | 50 | |
 |
A | 500 | 12 | 60 | 60 |
| B | 500 | 17 | 60 | 60 | |
| C | 1,500 | 91 | 60 | 92 | |
a
S : C = substrate : catalyst