Table 51.

Solvent-free MBH reaction catalyzed by organocatalysts A – C and DABCO (20 mol% each) from Figure 50.

entrya	product	cat	yield (%)	ee (%)
1		A	65b	77
2		C	quantc	60
3		A	quantc	38
4		C	65c	34
5		A	35c	79
6		C	79c	50
7		A	62c	90
8		A	28c	79
9		C	52b	69
10		C	quantb	rac
11		C	22b	58
12		C	quantb	rac
13		B	47c	22

^aThe reaction was carried out with 1 equiv of aldehyde and 4 equiv of enone or acrylate in the presence of 20 mol% catalyst and DABCO at 10°C for 72 h.

^bGC yield.

^cIsolated yield.