Table 53.
Catalytic asymmetric α-amination of butanone with (S)-proline.
 | ||||
|---|---|---|---|---|
| entry | cat (mol%) | solvent | time (h) | ee (%) |
| 1 | 20 | none | 65 | 92 |
| 2 | 10 | none | 65 | 93 |
| 3 | 5 | none | 65 | 93 |
| 4 | 20 | CH3CN | 52 | 96 |
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