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. 2008 Jun 23;1:32. doi: 10.1186/1756-0500-1-32

Figure 3.

Figure 3

PRNP haplotypes of the U.S. classical BSE case and her sire. (a) Physical map of haplotype networks one and two that span PRNP regions of high and low LD, respectively. (b) PRNP haplotype relationships. Circles represent PRNP haplotypes observed in a group of 86 U.S. Holsteins. Circle areas are proportional to haplotype frequencies. Rectangles represent haplotypes with a frequency of less than 2.5% in the Holstein group. Vertical brackets denote haplotypes with deletion alleles from a 23-bp and/or 12-bp InDel previously associated with classical BSE susceptibility. (c) PRNP diplotypes of the U.S. classical BSE case and her sire. The frequencies of diplotypes "Ab" and "Ae" in the Holstein group are 0.264 and 0.030, respectively.