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. 2008 Jul 29;8:215. doi: 10.1186/1471-2407-8-215

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Copyright © 2008 Zboralski et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Transient transfections with 4 kb promoter fragments of the three genes encoding LM-332. Normalized promoter activity as analyzed in transient transfections of each three Smad4-negative and Smad4-reexpressing SW480 and BxPC3 clones and of Smad4-positive LT97 adenoma cells. Bars show the mean value with the standard error of the mean. All three promoter constructs displayed increased constitutive activities in the Smad4-positive derivatives and all of them mediated Smad4-dependent TGFβ induction.