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. 2008 Jul 29;8:215. doi: 10.1186/1471-2407-8-215

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Copyright © 2008 Zboralski et al; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Compilation of functionally important bindings sites in the three LM-332 promoters. This scheme shows a summary of results reflecting the complexity of promoter regulation of LM-322. Indicated in the three promoters are the binding sites with significant importance for basal promoter activity "B"; for Smad4 dependent constitutive activity "SC" and for Smad4 dependent TGFβ induction "ST". In addition, binding of Smad4 as confirmed with ChIP analysis is indicated on top of the promoters.