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. 2008 Sep 2;118(10):3470–3477. doi: 10.1172/JCI35114

Figure 4. Egr-1 increases the viral loads in tissues and mortality of HSV-1–infected mice.

Figure 4

(A) The viral loads in the eyes and brains of Egr-1+/+ (n = 11), Egr-1+/– (n = 6), and Egr-1–/– (n = 8) mice infected with strain 294.1 at day 7 p.i. Data show mean ± SEM. *P = 0.005, Mann-Whitney U test. (B) Deaths of Egr-1+/+ (n = 32), Egr-1+/– (n = 11), and Egr-1–/– (n = 12) mice infected with strain 294.1. †P = 0.009, log-rank test. (C) Deaths of Egr-1+/+ (n = 20) and Egr-1–/– (n = 6) mice infected with strain dLAT2903.