TABLE 1.
Responses of individual neurons to application of acetylcholine (ACh) and cholinergic agonists
| Response |
ACh |
Nicotine | Musc or Oxo | |||
|---|---|---|---|---|---|---|
| +Ringer | +TTX | +Scop | +Mec | |||
| Depolarization | 57/79 | 27/33 | 8/8 | 1/11 | 18/19 | 4/68 |
| Mean ± SD, mV | 4.1 ± 2.2* | 5.6 ± 4.3 | 3.0 ± 2.9 | 5.6 ± 2.4 | 4.0 ± 2.6 | |
| Hyperpolarization | 7/79 | 3/33 | 0/8 | 0/11 | 1/19 | 19/68 |
| Mean ± SD, mV | 4.9 ± 2.8 | 5.3 ± 2.6 | 4.9 ± 3.3 | |||
| Depolarization + hyperpolarization | 7/79 | 2/33 | 0/8 | 1/11 | 0/19 | 1/68 |
| No change in membrane potential | 8/79 | 1/33 | 0/8 | 9/11 | 0/19 | 44/68 |
The neuronal responses recorded in normal Ringer solution or in TTX are counted together (except for the first two columns). Scop, muscarinic antagonist scopolamine; mec, nicotinic antagonist mecamylamine; musc and oxo, muscarinic agonists muscarine and oxotremorine, respectively.
*
Depicts the mean depolarization observed in neurons that were not brought to threshold.