Figure - PMC

Skip to main content

An official website of the United States government

Here's how you know

Here's how you know

Official websites use .gov
A .gov website belongs to an official government organization in the United States.

Secure .gov websites use HTTPS
A lock ( ) or https:// means you've safely connected to the .gov website. Share sensitive information only on official, secure websites.

View full-text article in PMC

. 1998 Aug 1;112(2):199–210. doi: 10.1085/jgp.112.2.199

Search in PMC
Search in PubMed
View in NLM Catalog
Add to search

This article is distributed under the terms of an Attribution–Noncommercial–Share Alike–No Mirror Sites license for the first six months after the publication date (see http://www.rupress.org/terms). After six months it is available under a Creative Commons License (Attribution–Noncommercial–Share Alike 4.0 Unported license, as described at http://creativecommons.org/licenses/by-nc-sa/4.0/).

PMC Copyright notice

Activation of the K_ACh channels by recombinant Gβ₁γ₅. (A1) Representative single-channel activity recorded in cell-attached configuration from an atrial myocyte in the presence of 1 μM adenosine. The membrane potential was clamped at −90 mV. (A2) Part of the trace in A1 (arrowhead) has been expanded to show the transitions between the closed and open states of the channel with a higher resolution. (B) Channel activity disappeared after the patch excision in GTP-free solution. The membrane potential continued to be clamped at −90 mV for the entire experiment. (C–D) Application of nanomolar concentrations of Gβ₁γ₅ (0.6 nM in C1 and 1.5 nM in D1) restored the channel activity in a concentration- dependent manner. Extended current traces starting at the points indicated by the arrowheads in C1 and D1 are shown on the right in C2 and D2, respectively.